Resistance to activated protein C: Role in venous and arterial thrombosis

被引：7
|
作者：
Emmerich, J [1 ]
AlhencGelas, M [1 ]
Aiach, M [1 ]
Fiessinger, JN [1 ]
机构：
[1] HOP BROUSSAIS,INSERM,U428,HEMOSTASE LAB,F-75674 PARIS 14,FRANCE
来源：
BIOMEDICINE & PHARMACOTHERAPY | 1996年 / 50卷 / 6-7期
关键词：
activated protein C resistance; factor V; thrombosis; thrombophilia; genetics;
D O I：
10.1016/0753-3322(96)84822-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Activated protein C resistance is the most prevalent cause of thrombophilia: it is found in 20 to 30% of patients with a deep venous thrombosis history. Activated protein C resistance is due to an arginine 506 to glutamine mutation in factor V. This mutation prevents normal inactivation of activated factor V by activated protein C. The estimated increase in relative risk of venous thrombosis is 5- to 10-fold in heterozygotes, and 50- to 100-fold in homozygotes. Activated protein C resistance does not seem to play a role in arterial thrombosis and in the occurrence of myocardial infarction.
引用
收藏
页码：254 / 260
页数：7
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