The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition

被引：37

作者：

Gulyás, B ^{[1
]}

Kéri, S

O'Sullivan, BT

Decety, J

Roland, PE

机构：

[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

[2] Univ Szeged, Dept Psychiat, Szeged, Hungary

[3] Univ Szeged, Dept Physiol, Szeged, Hungary

[4] Royal Prince Alfred Hosp, Dept Psychiat, Camperdown, NSW 2050, Australia

[5] Univ Washington, Ctr Mind Brain & Learning, Social Cognit Neurosci Lab, Seattle, WA 98195 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2004年 / 44卷 / 08期

关键词：

olfaction; human pheromones; social cognition; prefrontal cortex; superior temporal cortex; PET;

D O I：

10.1016/j.neuint.2003.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using O-15-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (gamma-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by gamma-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：595 / 600

页数：6

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