Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma

被引:10
|
作者
He, Chaobin [1 ]
Mao, Yize [1 ]
Lao, Xiangming [1 ]
Li, Shengping [1 ]
Lin, Xiaojun [1 ]
机构
[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Hepatobiliary Oncol,Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
combined hepatocellular cholangiocarcinoma; neutrophil-to-lymphocyte ratio; predict; overall survival; prognosis; PROGNOSTIC-SIGNIFICANCE; INTRAHEPATIC CHOLANGIOCARCINOMA; CURATIVE RESECTION; POOR-PROGNOSIS; OVARIAN-CANCER; CARCINOMA; INFLAMMATION; TUMOR; CYCLOOXYGENASE-2; HEPATECTOMY;
D O I
10.3892/ol.2018.7882
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The neutrophil-to-lymphocyte ratio (NLR) has been regarded as a prognostic factor in various types of cancer. The present study aimed to identify the association between NLR and combined hepatocellular cholangiocarcinoma (cHCC-CC) in patients who underwent surgical resection. The present study retrospectively reviewed 59 patients who were diagnosed with cHCC-CC and treated with surgical resection between January 2000 and October 2014 at the Department of Hepatobiliary and Pancreatic Surgery at Sun Yat-sen University Cancer Center (Guangzhou, China). The patients were divided into two groups: NLR <= 2.75 and NLR>2.75. Patients with stage I and II or stage III and IV disease were classified into early-and advanced-stage groups, respectively, according to the Tumor-Node-Metastasis (TNM) staging system. Overall survival time (OS) was estimated using the Kaplan-Meier method. Univariate and multivariate Cox regression models were used to evaluate the prognostic value of NLR. The NLR value was significantly higher in the HCC advanced-stage group compared with that in the HCC early-stage group according to the TNM staging system (3.19 vs. 2.00; P=0.001). The median survival time was 83.6 months in the NLR=2.75 group and 15 months in the NLR>2.75 group (P=0.004). Upon multivariate analysis, NLR>2.75 was an independent prognostic factor for poor cHCC-CC outcomes. Overall, the easily evaluated pre-treatment NLR may be an independent prognostic factor for patients with cHCC-CC treated by surgical resection.
引用
收藏
页码:4262 / 4268
页数:7
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