Sex hormones and cognitive decline in elderly men

被引：19

作者：

Muller, Majon ^{[1
,3
]}

van den Beld, Annewieke W. ^{[2
]}

Grobbee, Diederick E. ^{[3
]}

de Jong, Frank H. ^{[2
]}

Lamberts, Steven W. J. ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Geriatr, NL-3508 GA Utrecht, Netherlands

[2] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[3] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands

来源：

PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 01期

关键词：

Estradiol; Testosterone; Cognition; FREE TESTOSTERONE; ALZHEIMERS-DISEASE; MEMORY PERFORMANCE; RISK-FACTORS; OLDER MEN; WOMEN; DEMENTIA; ROTTERDAM; ESTRADIOL; HEALTH;

D O I：

10.1016/j.psyneuen.2008.08.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：27 / 31

页数：5

共 50 条

[1] Endogenous sex hormones, cognitive decline, and future dementia in old men
Geerlings, Mirjam I.
Strozyk, Dorothea
Masaki, Kamal
Remaley, Alan T.
Petrovitch, Helen
Ross, G. Webster
White, Lon R.
Launer, Lenore J.
[J]. ANNALS OF NEUROLOGY, 2006, 60 (03) : 346 - 355
[2] Sex hormones and neuropathology in elderly men: The HAAS
Strozyk, Dorothea
White, Lon R.
Petrovitch, Helen
Geerlings, Mirjam I.
Remaley, Alan T.
Launer, Lenore J.
[J]. NEUROBIOLOGY OF AGING, 2007, 28 (01) : 62 - 68
[3] Sex hormones and cognitive function in older men
Yaffe, K
Lui, LY
Zmuda, J
Cauley, J
[J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (04) : 707 - 712
[4] The cognitive neuropsychology of sex hormones in men and women
Janowsky, JS
Chavez, B
Zamboni, BD
Orwoll, E
[J]. DEVELOPMENTAL NEUROPSYCHOLOGY, 1998, 14 (2-3) : 421 - 440
[5] Endogenous sex hormones and cognitive function in the elderly
Lisa Boss
Duck-Hee Kang
Nancy Bergstrom
J. Leigh Leasure
[J]. Aging Clinical and Experimental Research, 2015, 27 : 515 - 521
[6] Endogenous sex hormones and cognitive function in the elderly
Boss, Lisa
Kang, Duck-Hee
Bergstrom, Nancy
Leasure, J. Leigh
[J]. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2015, 27 (04) : 515 - 521
[7] Endogenous sex hormones and cognitive function in older men
Barrett-Connor, E
Goodman-Gruen, D
Patay, B
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10): : 3681 - 3685
[8] SEX-HORMONES AND COGNITIVE-FUNCTIONING IN MEN
CHRISTIANSEN, K
KNUSSMANN, R
[J]. NEUROPSYCHOBIOLOGY, 1987, 18 (01) : 27 - 36
[9] EFFECTS OF SEX HORMONES ON COGNITIVE STYLE IN RATS AND MEN
DAWSON, JLM
[J]. BEHAVIOR GENETICS, 1972, 2 (01) : 21 - 42
[10] Does testosterone mediate cognitive decline in elderly men?
Moffat, SD
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (05): : 521 - 521

← 1 2 3 4 5 →