Adult Behavior in Male Mice Exposed to E-Cigarette Nicotine Vapors during Late Prenatal and Early Postnatal Life

被引:71
|
作者
Smith, Dani [1 ]
Aherrera, Angela [2 ]
Lopez, Armando [2 ,3 ]
Neptune, Enid [3 ]
Winickoff, Jonathan P. [4 ,5 ,6 ]
Klein, Jonathan D. [4 ]
Chen, Gang [7 ]
Lazarus, Philip [7 ]
Collaco, Joseph M. [2 ,4 ]
McGrath-Morrow, Sharon A. [2 ,4 ]
机构
[1] Johns Hopkins Univ, Dept Psychol & Brain Sci, Neurogenet & Behav Ctr, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Eudowood Div Pediat Resp Sci, Baltimore, MD 21218 USA
[3] Johns Hopkins Med Inst, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21205 USA
[4] Amer Acad Pediat, Julius B Richmond Ctr Excellence, Elk Grove Village, IL USA
[5] Massachusetts Gen Hosp, Div Gen Pediat, Boston, MA 02114 USA
[6] Harvard Univ, Sch Med, Boston, MA USA
[7] Washington State Univ, Dept Pharmacol, Pullman, WA 99164 USA
来源
PLOS ONE | 2015年 / 10卷 / 09期
基金
美国国家卫生研究院;
关键词
C57BL/6J MICE; SMOKE EXPOSURE; TERATOGENICITY; HYPERACTIVITY; PERFORMANCE; COTININE; ANXIETY; BRAIN; RISK; TIME;
D O I
10.1371/journal.pone.0137953
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nicotine exposure has been associated with an increased likelihood of developing attention deficit hyperactivity disorder (ADHD) in offspring of mothers who smoked during pregnancy. The goal of this study was to determine if exposure to E-cigarette nicotine vapors during late prenatal and early postnatal life altered behavior in adult mice. Methods Timed-pregnant C57BL/6J mice were exposed to 2.4% nicotine in propylene glycol (PG) or 0% nicotine/PG once a day from gestational day 15 until delivery. After delivery, offspring and mothers were exposed to E-cigarette vapors for an additional 14 days from postnatal day 2 through 16. Following their last exposure serum cotinine levels were measured in female juvenile mice. Male mice underwent behavioral testing at 14 weeks of age to assess sensorimotor, affective, and cognitive functional domains. Results Adult male mice exposed to 2.4% nicotine/PG E-cigarette vapors had significantly more head dips in the zero maze test and higher levels of rearing activity in the open field test compared to 0% nicotine/ PG exposed mice and untreated controls. In the water maze test after reversal training, the 2.4% nicotine/ PG mice spent more than 25% of time in the new location whereas the other groups did not. Conclusion Adult male mice exhibited increased levels of activity in the zero maze and open field tests when exposed to E-cigarette vapor containing nicotine during late prenatal and early postnatal life. These findings indicate that nicotine exposure from E-cigarettes may cause persistent behavioral changes when exposure occurs during a period of rapid brain growth.
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页数:14
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