Native-like Env trimers as a platform for HIV-1 vaccine design

被引:185
|
作者
Sanders, Rogier W. [1 ,2 ]
Moore, John P. [1 ]
机构
[1] Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10021 USA
[2] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands
基金
欧洲研究理事会;
关键词
Env trimers; HIV-1; vaccines; neutralizing antibodies; IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE GLYCOPROTEIN TRIMERS; BROADLY NEUTRALIZING ANTIBODIES; CRYO-EM STRUCTURE; B-CELL RECEPTORS; CRYSTAL-STRUCTURE; AFFINITY MATURATION; GP140; TRIMERS; RECOMBINANT GLYCOPROTEIN-120; PROTEOLYTICALLY MATURE;
D O I
10.1111/imr.12481
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.
引用
收藏
页码:161 / 182
页数:22
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