Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

被引：10

作者：

Li, Hongqing ^{[1
]}

Zhang, Yongmin ^{[1
]}

Favre, Sylvain ^{[2
]}

Vogel, Pierre ^{[2
]}

Sollogoub, Matthieu ^{[1
]}

Bleriot, Yves ^{[1
]}

机构：

[1] Univ Paris 06, Inst Parisien Chim Mol, CNRS, UMR 7201,FR 2769, F-75005 Paris, France

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, BCH, CH-1015 Lausanne, Switzerland

来源：

CARBOHYDRATE RESEARCH | 2012年 / 356卷

关键词：

Iminosugar; Glycosidase; Inhibitor; Azepane; TYPE-2; DIABETES-MELLITUS; THERAPEUTIC APPLICATIONS; ISOFAGOMINE; POTENT; AGENTS; GLUCOSIDASE; IMINOSUGARS; CATION; RING; TETRAHYDROXYAZEPANES;

D O I：

10.1016/j.carres.2011.10.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：110 / 114

页数：5

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