Structure, Function, and Modulation of GABAA Receptors

被引：520
|
作者：
Sigel, Erwin [1 ]
Steinmann, Michael E. [1 ]
机构：
[1] Univ Bern, Inst Biochem & Mol Med, CH-3012 Bern, Switzerland
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 48期
基金：
瑞士国家科学基金会;
关键词：
BENZODIAZEPINE BINDING-SITE; GATED ION-CHANNEL; NICOTINIC ACETYLCHOLINE-RECEPTOR; AMINOBUTYRIC ACID(A) RECEPTORS; BOVINE CEREBRAL-CORTEX; A RECEPTORS; SUBUNIT COMPOSITION; INTERNATIONAL UNION; AGONIST BINDING; DELTA-SUBUNIT;
D O I：
10.1074/jbc.R112.386664
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABA(A) receptors located in the postsynaptic membrane mediate neuronal inhibition that occurs in the millisecond time range; those located in the extrasynaptic membrane respond to ambient GABA and confer long-term inhibition. GABA(A) receptors are responsive to a wide variety of drugs, e.g. benzodiazepines, which are often used for their sedative/hypnotic and anxiolytic effects.
引用
收藏
页码：40224 / 40231
页数：8
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