Biochip technology for monitoring posttraumatic stress disorder (PTSD)

被引:11
|
作者
Lee, Jung-Hyun [1 ]
Jung, Hyo-Il [1 ]
机构
[1] Yonsei Univ, Sch Mech Engn, Seoul 120749, South Korea
基金
新加坡国家研究基金会;
关键词
Posttraumatic stress disorder (PTSD); biomarkers; biochip; DEXAMETHASONE SUPPRESSION TEST; PLATELET SEROTONIN; SYMPTOM SEVERITY; CORTISOL-LEVELS; HEART-RATE; PLASMA; MARKERS; DEPRESSION; SURVIVORS; SYSTEM;
D O I
10.1007/s13206-013-7301-x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Posttraumatic stress disorder (PTSD) is an anxiety-related disorder that occurs after an exposure to an emotionally traumatic event, such as a life-threatening experience, and that persists with intrusive and distressing emotion-laden memories. It can trigger further mental health problems, such as depression, bipolar disorder, mania and so on. As a large population suffers from these complex diseases, its treatment results in massive secondary costs to society. Recent diagnosis and treatment of PTSD is based on relatively subjective assessments through diverse symptoms checklists, clinical histories, mental status exams, patient self-reports, and symptom duration. Biological markers have not been identified, and a biochip for PTSD has not yet been developed. In this paper, we briefly review potential biomarkers that could be used to determine the disease stage of PTSD, and we propose new applications of biochip technology with which PTSD could be precisely measured in real time using body fluids, such as blood, saliva, and urine. Microfabrication techniques have made it possible to construct nano/micron-scale sensing parts/chips to accommodate molecular linkers and capture the biomarkers for PTSD. These techniques provide new opportunities to diagnose PTSD in a precise manner.
引用
收藏
页码:195 / 200
页数:6
相关论文
共 50 条
  • [1] Biochip technology for monitoring posttraumatic stress disorder (PTSD)
    Jung-Hyun Lee
    Hyo-Il Jung
    [J]. BioChip Journal, 2013, 7 : 195 - 200
  • [2] Actigraphic sleep monitoring in posttraumatic stress disorder (PTSD) patients
    Dagan, Y
    Zinger, Y
    Lavie, P
    [J]. JOURNAL OF PSYCHOSOMATIC RESEARCH, 1997, 42 (06) : 577 - 581
  • [3] Nightmares and Posttraumatic Stress Disorder (PTSD)
    Campbell R.L.
    Germain A.
    [J]. Current Sleep Medicine Reports, 2016, 2 (2) : 74 - 80
  • [4] Genetics of Posttraumatic Stress Disorder (PTSD)
    Weiss, Elisabeth M.
    Parson, Walther
    Niederstatter, Harald
    Marksteiner, Josef
    Lampe, Astrid
    [J]. PSYCHOTHERAPIE PSYCHOSOMATIK MEDIZINISCHE PSYCHOLOGIE, 2019, 69 (07) : 266 - 274
  • [5] Proteomics and Posttraumatic Stress Disorder (PTSD)
    Kozaric-Kovacic, Dragica
    Pavelic, Kresimir
    Filipac, Vanda
    Cindric, Mario
    Vucinic, Srdan
    Kraljevic-Pavelic, Sandra
    [J]. COPING WITH POSTTRAUMATIC STRESS DISORDER IN RETURNING TROOPS: WOUNDS OF WAR II, 2010, 68 : 57 - 66
  • [6] PTSD: Posttraumatic stress disorder or posttraumatic sleep disorders?
    Haynes, PL
    Krakow, B
    Warner, TD
    Melendrez, D
    Hollifield, M
    Koss, M
    [J]. SLEEP, 2003, 26 : A380 - A380
  • [7] Gender differences in posttraumatic stress disorder (PTSD)
    Bise, S.
    Sulejmanpasic, G.
    Zukic, I.
    [J]. EUROPEAN PSYCHIATRY, 2019, 56 : S201 - S201
  • [8] Understanding posttraumatic stress disorder (PTSD): An overview
    Yehuda, R
    [J]. JOURNAL OF CLINICAL PSYCHIATRY, 2001, 62 : 3 - 3
  • [9] Posttraumatic stress disorder (PTSD): The malleable diagnosis?
    Eagle, GT
    [J]. SOUTH AFRICAN JOURNAL OF PSYCHOLOGY, 2002, 32 (02) : 37 - 42
  • [10] Posttraumatic stress disorder (PTSD) and the dermatology patient
    Gupta, Madhulika A.
    Jarosz, Patricia
    Gupta, Aditya K.
    [J]. CLINICS IN DERMATOLOGY, 2017, 35 (03) : 260 - 266