Precancerous lesions of the pancreas

被引：53

作者：

Zamboni, Giuseppe ^{[1
,2
]}

Hirabayashi, Kenichi ^{[2
,3
]}

Castelli, Paola ^{[2
]}

Lennon, Anne Marie ^{[4
]}

机构：

[1] Univ Verona, Dept Pathol, I-37100 Verona, Italy

[2] Osped Sacro Cuore Don Calabria, Dept Pathol, I-37024 Verona, Italy

[3] Tokai Univ, Dept Pathol, Sch Med, Isehara, Kanagawa 2591193, Japan

[4] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2013年 / 27卷 / 02期

关键词：

Pancreas; Precancerous lesions; Pancreatic cancer; Pancreatic neoplasms; Pathology; PAPILLARY-MUCINOUS NEOPLASMS; TERM-FOLLOW-UP; INTERNATIONAL CONSENSUS GUIDELINES; GENE-EXPRESSION PROFILES; HIGH-RISK INDIVIDUALS; INTRADUCTAL PAPILLARY; CYSTIC NEOPLASMS; INTRAEPITHELIAL NEOPLASIA; CLINICOPATHOLOGICAL FEATURES; DUCTAL ADENOCARCINOMA;

D O I：

10.1016/j.bpg.2013.04.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer has a very poor prognosis, with a five year survival of only 5%. New studies have shown that it takes over 11 years for cells to develop invasive capability. This provides an opportunity to intervene if precursor lesions can be detected. This paper reviews the molecular, pathological, clinical findings and management of pancreatic intra-epithelial neoplasia (PanIN), intraductal pancreatic mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), three precursor lesions which can give rise to invasive carcinoma of the pancreas. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：299 / 322

页数：24

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