Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel

被引：22
|
作者：
Shinohara, Naoki [1 ]
Itoh, Hiroaki [1 ]
Matsuoka, Shigeru [1 ]
Inoue, Masayuki [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
CHEMMEDCHEM | 2012年 / 7卷 / 10期
基金：
日本学术振兴会;
关键词：
cytotoxic agents; natural products; nonribosomal peptides; structure-activity relationships; synthetic ion channels; MARINE SPONGE; GRAMICIDIN-A; TRANSMEMBRANE CHANNEL; FUNCTIONAL-ANALYSIS; PEPTIDE; POLYPEPTIDES; MEMBRANE; PROTEINS; BEHAVIOR; ASSAY;
D O I：
10.1002/cmdc.201200142
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：1770 / 1773
页数：4
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