Solid phase synthesis of polylactosamine oligosaccharide

被引：54

作者：

Shimizu, H ^{[1
]}

Ito, Y ^{[1
]}

Kanie, O ^{[1
]}

Ogawa, T ^{[1
]}

机构：

[1] RIKEN,INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(96)00535-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid phase synthesis of polylactosamine oligosaccharide was performed starting from resin supported lactose 1a,b. Glycosylation of 1a with the lactosamine unit 6 followed by delevulinoylation afforded tetrasaccharides, which were further converted into hexa- and octasaccharide and was cleaved from resin by TrBF(4) in CH2Cl2 to afford 7. Ester linked Ib was converted in a similar manner into hexasaccharide that was liberated under basic conditions to give 8. Subsequent deprotection into 9 was performed in three steps. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2841 / 2846

页数：6

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