Palladium-Catalyzed Direct Intermolecular α-Arylation of Amides with Aryl Chlorides

被引：72
|
作者：
Zheng, Bing [1 ,2 ]
Jia, Tiezheng [2 ]
Walsh, Patrick J. [2 ]
机构：
[1] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China
[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Penn Merck Lab High Throughput Experimentat, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 16期
基金：
美国国家科学基金会;
关键词：
HETEROCYCLIC CARBENE LIGANDS; C-H BONDS; COUPLING REACTIONS; PRECATALYSTS; OXINDOLES; CARBONYL; HALIDES; SCALE; MILD;
D O I：
10.1021/ol4019002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient catalytic system for the direct intermolecular alpha-arylation of acetamide derivatives with aryl chlorides is presented. Chemoselectivities up to 10:1 in the mono- and diarylation of acetamides were achieved by careful selection of bases, solvents, and stoichiometry. Bis-arylated amides were prepared in up to 95% yield.
引用
收藏
页码：4190 / 4193
页数：4
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