Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints

被引：156
|
作者：
Sardaro, Angela [1 ]
Petruzzelli, Maria Fonte [2 ]
D'Errico, Maria Patrizia [3 ]
Grimaldi, Luca [4 ]
Pili, Giorgio [4 ]
Portaluri, Maurizio [2 ,5 ]
机构：
[1] Policlin Bari, Univ Inst Radiat Oncol, Bari, Italy
[2] A Perrino Hosp, Dept Radiotherapy, I-72100 Brindisi, Italy
[3] A Perrino Hosp, Dept Lab Med, I-72100 Brindisi, Italy
[4] A Perrino Hosp, Dept Phys Med, I-72100 Brindisi, Italy
[5] IFC CNR, Natl Res Council, Inst Clin Physiol, Pisa, Italy
来源：
RADIOTHERAPY AND ONCOLOGY | 2012年 / 103卷 / 02期
关键词：
Cardiac damage; Radiotherapy; Breast cancer; Dosimetric constraints; Biological parameters; INDUCED HEART-DISEASE; INFLAMMATORY PLAQUE PHENOTYPE; CARDIOVASCULAR MORTALITY; ADJUVANT RADIOTHERAPY; IONIZING-RADIATION; INDUCED ATHEROMATOSIS; CONSERVATIVE SURGERY; NATRIURETIC-PEPTIDE; RANDOMIZED-TRIAL; NORMAL TISSUE;
D O I：
10.1016/j.radonc.2012.02.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Today there is general awareness of the potential damage to the heart in left-sided (more than in right-sided) breast cancer radiotherapy (RT). Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Individual and pharmacological risk factors are also examined with respect to radiation damage. The biological mechanisms of harm are only partially understood, such as the radiobiology of heart damage due to the presence of various radiosensitive structures and their topographic heterogeneity. Furthermore, individual variability may expose patients to higher or lower risks of late cardiac damage or death. Damage mechanisms and radiobiological characteristics in heart irradiation are presented in relation to dosimetric and biological parameters. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 103 (2012) 133-142
引用
收藏
页码：133 / 142
页数：10
相关论文
共 50 条
  • [41] Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes
    López, E
    Guerrero, R
    Núñez, MI
    del Moral, R
    Villalobos, M
    Martínez-Galán, J
    Valenzuela, MT
    Muñoz-Gámez, J
    Oliver, FJ
    Martín-Oliva, D
    de Almodóvar, JMR
    BREAST CANCER RESEARCH, 2005, 7 (05): : R690 - R698
  • [42] Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes
    Escarlata López
    Rosario Guerrero
    Maria Isabel Núñez
    Rosario del Moral
    Mercedes Villalobos
    Joaquina Martínez-Galán
    Maria Teresa Valenzuela
    José Antonio Muñoz-Gámez
    Francisco Javier Oliver
    David Martín-Oliva
    José Mariano Ruiz de Almodóvar
    Breast Cancer Research, 7
  • [43] Radiation-induced heart disease in breast cancer patients: a narrative review of epidemiology, risk factors, radiotherapy parameters, and prevention
    van der Vorst, Aline
    Lambrecht, Maarten
    Van Aelst, Lucas
    Verhoeven, Jelle
    Jacobs, Johanna
    Baten, Adinda
    Weltens, Caroline
    STRAHLENTHERAPIE UND ONKOLOGIE, 2025, 201 (04) : 368 - 382
  • [44] Clinical and dosimetric risk factors of radiation-induced acute esophageal toxicity in non-small cell lung cancer
    Zhang, Z. C.
    Li, B. S.
    Xu, J.
    Yin, Y.
    Lu, J.
    Li, H. S.
    Sun, H. F.
    Wang, Z. T.
    Liu, J.
    Liu, B.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 72 (01): : S461 - S461
  • [45] Radiation-induced cancer risk in breast cancer patients. Boost by photons or electrons? Definitive results
    Alastuey, I.
    Arino, A.
    Vara, J.
    Castejon, M. A.
    Pardo, J.
    Font, J.
    Montemuino, S.
    Ortiz, I.
    RADIOTHERAPY AND ONCOLOGY, 2015, 115 : S578 - S579
  • [46] Mutational Landscape of Radiation-Induced Angiosarcoma in Breast Cancer Patients
    Siddiqui, Z. A., Jr.
    Thibodeau, B. J.
    Ahmed, S.
    Dekhne, N. S.
    Benitez, P. R.
    Amin, M. B.
    Grills, I. S.
    Wobb, J. L.
    Wilson, G. D.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 99 (02): : S55 - S55
  • [47] Radiation-induced modulation in the distribution of lymphocytes in breast cancer patients
    Sage, E. K.
    Sedelmayr, M.
    Gehrmann, M.
    Bayer, C.
    Schilling, D.
    Duma, M. N.
    Schmid, T. E.
    Geinitz, H.
    Multhoff, G.
    ONCOLOGY RESEARCH AND TREATMENT, 2014, 37 : 12 - 12
  • [48] Radiation-induced modulation in the distribution of lymphocytes in breast cancer patients
    Sage, E. K.
    Sedelmayr, M.
    Gehrmann, M.
    Bayer, C.
    Schilling, D.
    Duma, M. N.
    Schmid, T. E.
    Multhoff, G.
    Geinitz, H.
    RADIOTHERAPY AND ONCOLOGY, 2014, 111 : S301 - S301
  • [49] Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients
    Nalbantov, Georgi
    Kietselaer, Bas
    Vandecasteele, Katrien
    Oberije, Cary
    Berbee, Maaike
    Troost, Esther
    Dingemans, Anne-Marie
    van Baardwijk, Angela
    Smits, Kim
    Dekker, Andre
    Bussink, Johan
    De Ruysscher, Dirk
    Lievens, Yolande
    Lambin, Philippe
    RADIOTHERAPY AND ONCOLOGY, 2013, 109 (01) : 100 - 106
  • [50] Current Cardioprotective Strategies for the Prevention of Radiation-Induced Cardiotoxicity in Left-Sided Breast Cancer Patients
    Nikovia, Vasiliki
    Chinis, Evangelos
    Gkantaifi, Areti
    Marketou, Maria
    Mazonakis, Michalis
    Charalampakis, Nikolaos
    Mavroudis, Dimitrios
    Orfanidou, Kornilia Vasiliki
    Varveris, Antonios
    Antoniadis, Chrysostomos
    Tolia, Maria
    JOURNAL OF PERSONALIZED MEDICINE, 2023, 13 (07):
12345