Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

被引：7

作者：

Dimou, Niki ^{[1
]}

Omiyale, Wemimo ^{[2
,3
]}

Biessy, Carine ^{[1
]}

Viallon, Vivian ^{[1
]}

Kaaks, Rudolf ^{[4
]}

O'Mara, Tracy A. ^{[5
]}

Aglago, Elom K. ^{[1
]}

Ardanaz, Eva ^{[6
,7
,8
]}

Bergmann, Manuela M. ^{[9
]}

Bondonno, Nicola P. ^{[10
]}

Braaten, Tonje ^{[11
]}

Colorado-Yohar, Sandra M. ^{[8
,12
,13
]}

Crous-Bou, Marta ^{[14
,15
]}

Dahm, Christina C. ^{[16
]}

Fortner, Renee T. ^{[4
]}

Gram, Inger T. ^{[11
]}

Harlid, Sophia ^{[17
]}

Heath, Alicia K. ^{[18
]}

Idahl, Annika ^{[17
]}

Kvaskoff, Marina ^{[19
]}

Nost, Therese H. ^{[11
,20
]}

Overvad, Kim ^{[16
]}

Palli, Domenico ^{[21
]}

Perez-Cornago, Aurora ^{[22
]}

Sacerdote, Carlotta ^{[23
]}

Sanchez, Maria-Jose ^{[24
,25
,26
,27
]}

Schulze, Matthias B. ^{[28
,29
]}

Severi, Gianluca ^{[19
,30
]}

Simeon, Vittorio ^{[31
]}

Tagliabue, Giovanna ^{[32
]}

Tjonneland, Anne ^{[33
]}

Truong, Therese ^{[19
]}

Tumino, Rosario ^{[34
]}

Johansson, Mattias ^{[35
]}

Weiderpass, Elisabete ^{[36
]}

Murphy, Neil ^{[1
]}

Gunter, Marc J. ^{[1
]}

Lacey, Ben ^{[2
,3
]}

Allen, Naomi E. ^{[2
,3
]}

Dossus, Laure ^{[1
]}

机构：

[1] Int Agcy Res Canc, Nutr & Metab Branch, Lyon, France

[2] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[3] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

[4] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[5] QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia

[6] Navarra Publ Hlth Inst, Pamplona, Spain

[7] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[8] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[9] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[10] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[11] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[12] IMIB Arrixaca, Dept Epidemiol, Murcia Reg Hlth Council, Murcia, Spain

[13] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[14] Catalan Inst Oncol ICO, Unit Nutr & Canc, Canc Epidemiol Res Program, Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain

[15] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[16] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[17] Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden

[18] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[19] Univ Paris Saclay, Exposome & Hered Team, Inserm CESP U1018, UVSQ,Gustave Roussy, Villejuif, France

[20] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway

[21] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[22] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[23] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[24] Escuela Andaluza Salud Publ EASP, Granada, Spain

[25] Inst Invest Biosanitaria IbsGRANADA, Granada, Spain

[26] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[27] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[28] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[29] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany

[30] Univ Florence, Dept Stat Comp Sci Applicat G Parenti, Florence, Italy

[31] Univ Naples L Vanvitelli, Dipartimento Salute Mentale & Fis & Med Prevent, Naples, Italy

[32] Fdn IRCCS Ist Nazl Tumori, Dept Res, Via Venezian 1, Milan, Italy

[33] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[34] AIRE ONLUS, Hyblean Assoc Epidemiol Res, Ragusa, Italy

[35] Int Agcy Res Canc, Sect Genet, Lyon, France

[36] World Hlth Org, Int Agcy Res Canc, Off Director, Lyon, France

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2022年 / 31卷 / 09期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

GENETIC-VARIANTS; SEX-HORMONES; IDENTIFICATION; REGRESSION; ESTROGENS; OVERLAP; OBESITY; BREAST; WOMEN; INDEX;

D O I：

10.1158/1055-9965.EPI-21-1176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. How-ever, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.

引用

页码：1839 / 1848

页数：10

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