Cutaneous lupus induced by etanercept in rheumatoid arthritis

被引：4
|
作者：
Abourazzak, F. E. [1 ]
Guggenbuhl, P. [2 ]
Perdriger, A. [2 ]
Meadeb, J. [2 ]
Gando-Cocley, N. [2 ]
Chevrant-Breton, J. [3 ]
Hajjaj-Hassouni, N. [1 ]
Chales, G. [2 ]
机构：
[1] CHU Rabat Sale, Hop El Ayachi, Serv Rhumatol, Rabat 10000, Morocco
[2] CHU Rennes, Hop Sud, Serv Rhumatol, Rennes, France
[3] CHU Rabat Sale, Hop Pontchaillou, Serv Dermatol, Rabat 10000, Morocco
来源：
REVUE DE MEDECINE INTERNE | 2008年 / 29卷 / 09期
关键词：
rheumatoid arthritis; etanercept; drug-induced lupus;
D O I：
10.1016/j.revmed.2008.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Therapy with anti-TNF alpha in rheumatoid arthritis may induce autoimmune disorders. Induction of autoantibodies is frequently observed, but lupus-like syndrome is rare and few cases only have been reported. We report a 41-year-old female, treated with etanercept for a rheumatoid arthritis, who developed a cutaneous lupus induced without any other organ involvement, associated with high ANA and DNA antibody titres. The skin biopsy and the histological analysis with immunofluorescence confirmed the diagnosis. The anti-TNFa treatment was stopped. Corticosteroids were increased and hydroxychloroquine administered because skin lesions persist after three months. (C) 2008 Elsevier Masson SAS. Tous droits reserves.
引用
收藏
页码：744 / 747
页数：4
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