Dehydration Status Predicts Short-Term and Long-Term Outcomes in Patients with Cerebral Venous Thrombosis

被引:18
|
作者
Liu, Kai [1 ]
Pei, Lulu [1 ]
Gao, Yuan [1 ]
Zhao, Lu [1 ]
Fang, Hui [1 ]
Bunda, Bridget [2 ,3 ,4 ]
Fisher, Lindsay [2 ,3 ,4 ]
Wang, Yunchao [1 ]
Li, Shen [1 ]
Li, Yusheng [1 ]
Guan, Sheng [5 ]
Guo, Xinbin [5 ]
Xu, Haowen [5 ]
Xu, Yuming [1 ]
Song, Bo [1 ]
机构
[1] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, 1 Eastern Jianshe Rd, Zhengzhou 450052, Henan, Peoples R China
[2] Massachusetts Gen Hosp, Cardioneurol Clin, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Clin Prote Res Ctr, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Neuroprotect Res Lab, Boston, MA 02114 USA
[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Intervent Neurol, Zhengzhou, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
Cerebral venous thrombosis; Dehydration; Blood urea; creatinine ratio; Prognosis; Mortality; Risk factors; UREA NITROGEN/CREATININE RATIO; HYDRATION THERAPY; STROKE; THROMBOEMBOLISM; VEIN;
D O I
10.1007/s12028-018-0628-3
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
BackgroundDehydration is associated with a higher risk of poor outcome and venous thromboembolism in acute ischemic stroke patients. However, the relationship between dehydration and prognosis in patients with cerebral venous thrombosis (CVT) has not yet been investigated.MethodsConsecutive CVT patients at the First Affiliated Hospital of Zhengzhou University were retrospectively identified from November 2011 through January 2017. Dehydration was evaluated by blood urea/creatinine (U/Cr) ratio>80. Poor functional outcome was defined as modified Rankin Scale (mRS) of 3-6. Factors such as age, sex, coma, intracerebral hemorrhage, and straight sinus and/or deep CVT involved were adjusted to assess the relationship between dehydration, and prognosis at discharge and long-term follow-up in CVT patients.ResultsA total of 220 CVT patients were included, and 85 patients (38.64%) were dehydrated. Multivariate logistic regression analysis indicated that patients with dehydration had a higher risk of mRS of 3-6 at discharge (adjusted odds ratio [OR] 3.629, 95% confidence intervals [CI] 1.526-8.633, P=0.004) and long-term outcome (adjusted OR 3.831, 95% CI 1.597-9.190, P=0.003). Subgroup analysis stratified by potential factors that might be associated with dehydration, such as infection, vomiting, pregnancy, and/or postpartum, showed similar results. Multivariate Cox regression analysis further demonstrated that dehydration was associated with higher mortality (adjusted hazard ratio [HR]=2.301, 95% CI 1.025-5.166, P=0.043).ConclusionsThe present findings indicate that dehydration is an independent predictor for short-term and long-term unfavorable functional outcome in patients with CVT.
引用
收藏
页码:478 / 483
页数:6
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