Systemic treatment for hereditary cancers: a 2012 update

被引:6
|
作者
Imyanitov, Evgeny N. [1 ,2 ,3 ]
Byrski, Tomasz [4 ,5 ]
机构
[1] NN Petrov Inst Oncol, Mol Oncol Lab, St Petersburg 197758, Russia
[2] St Petersburg Pediat Med Univ, Dept Med Genet, St Petersburg 194100, Russia
[3] II Mechnikov North Western Med Univ, Dept Oncol, St Petersburg 191015, Russia
[4] Pomeranian Med Univ, Int Hereditary Canc Ctr, PL-70111 Szczecin, Poland
[5] Pomeranian Med Univ, Clin Oncol, PL-70111 Szczecin, Poland
关键词
PEGYLATED LIPOSOMAL DOXORUBICIN; PATHOLOGICAL COMPLETE RESPONSE; EPITHELIAL OVARIAN-CANCER; MEDULLARY-THYROID CANCER; NEGATIVE BREAST-CANCER; OPEN-LABEL; PANCREATIC ADENOCARCINOMA; SOMATIC MUTATIONS; BRCA MUTATIONS; PHASE-II;
D O I
10.1186/1897-4287-11-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The history of specific therapy for hereditary tumors dates back to mid 1980s and involves a number of reports demonstrating regression of familial colon polyps upon administration of sulindac. Virtually no clinical studies on other hereditary cancer types were available until the year 2009, when Byrski et al. presented the data on unprecedented sensitivity of BRCA1-associated breast malignancies to cisplatin. This breakthrough has revived interest to the treatment of cancer in germ-line mutation carriers. Recent trials and clinical observations have confirmed the efficacy of platinating agents and PARP inhibitors in BRCA1/2-driven breast, ovarian and pancreatic carcinomas. Pegylated liposomal doxorubicin may be considered as a promising treatment option for BRCA1/2-related ovarian cancer after the failure of platinum-containing therapy. Several novel drugs have been recently introduced in the management of rare familial tumor syndromes. Vandetanib, a low-molecular weight RET kinase inhibitor, demonstrated substantial efficacy in the treatment of hereditary and sporadic medullary thyroid cancer. Vismodegib, an inhibitor of SMO oncoprotein, caused regression of basal-cell carcinomas in patients with Gorlin syndrome. Down-regulation of mTOR kinase by everolimus has been successfully used for the therapy of subependymal giant-cell astrocytomas in patients with tuberous sclerosis. The achievements in the prevention, diagnostics and treatment of hereditary cancers may serve as an excellent example of triumph of translational medicine.
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页数:5
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