Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

被引：52

作者：

Bozec, Alexandre ^{[1
,2
]}

Ilie, Marius ^{[2
,3
,4
]}

Dassonville, Olivier ^{[1
]}

Long, Elodie ^{[2
,3
]}

Poissonnet, Gilles ^{[1
]}

Santini, Jose ^{[1
]}

Chamorey, Emmanuel ^{[5
]}

Ettaiche, Marc ^{[5
]}

Chauviere, Damien ^{[5
]}

Peyrade, Frederic ^{[6
]}

Hebert, Christophe ^{[6
]}

Benezery, Karen ^{[7
]}

Sudaka, Anne ^{[8
]}

Haudebourg, Juliette ^{[8
]}

Selva, Eric ^{[4
]}

Hofman, Paul ^{[2
,3
,4
]}

机构：

[1] Inst Univ Face & Cou, Dept Surg, F-06103 Nice, France

[2] IRCAN Inserm U1081 Team 3, Fac Med, F-06107 Nice, France

[3] Pasteur Hosp, Lab Clin & Expt Pathol, F-06002 Nice, France

[4] Pasteur Hosp, Human Biobank, F-06002 Nice, France

[5] Ctr Antoine Lacassagne, Dept Stat, F-06189 Nice, France

[6] Ctr Antoine Lacassagne, Dept Med Oncol, F-06189 Nice, France

[7] Ctr Antoine Lacassagne, Dept Radiotherapy, F-06189 Nice, France

[8] Ctr Antoine Lacassagne, Dept Pathol, F-06189 Nice, France

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2013年 / 270卷 / 10期

关键词：

Head and neck squamous cell carcinoma; Oral cavity; Oropharynx; Circulating tumor cells; CellSearch system; METASTATIC BREAST-CANCER; SURGERY; BLOOD; SIZE;

D O I：

10.1007/s00405-013-2399-y

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The objective of this study was to evaluate the potential detection of circulating tumor cells (CTCs) using the CellSearch (CS) Assay (TM) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) and then to identify the clinical factors predictive of the presence of CTCs. The presence and number of CTCs were determined using the CS system before treatment, and in 10 healthy individuals (control group). The CS system was able to successfully identify the presence of CTCs in 8 of 49 patients (16 %) before therapy. No CTC was found in the control group. CTCs were detected before therapy in 1 of 19 patients (5 %) with N0 tumor and in 7 of 30 patients (23 %) with N1-2c tumor (p = 0.12; Fisher's exact test). CTCs were identified in a relatively low proportion of patients with locally advanced HNSCC.

引用

页码：2745 / 2749

页数：5

共 50 条

[1] Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma
Alexandre Bozec
Marius Ilie
Olivier Dassonville
Elodie Long
Gilles Poissonnet
José Santini
Emmanuel Chamorey
Marc Ettaiche
Damien Chauvière
Frédéric Peyrade
Christophe Hebert
Karen Benezery
Anne Sudaka
Juliette Haudebourg
Eric Selva
Paul Hofman
[J]. European Archives of Oto-Rhino-Laryngology, 2013, 270 : 2745 - 2749
[2] Significance of Circulating Tumor Cells (CTCs) detection using the CellSearch system in patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Bozec, A.
Ilie, M.
Long, E.
Dassonville, O.
Poissonnet, G.
Santini, J.
Chamorey, E.
Peyrade, F.
Benezery, K.
Sudaka, A.
Selva, E.
Hofman, P.
[J]. VIRCHOWS ARCHIV, 2012, 461 : S28 - S28
[3] Clinical significance of circulating tumor cells in patients with locally advanced head and neck squamous cell carcinoma
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[6] Detection and clinical significance of circulating tumor cells in squamous cell carcinoma of the head and neck
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[J]. PLOS ONE, 2014, 9 (12):
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