The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates

被引：0

作者：

Gangwar, Ssnjeev ^{[1
]}

Pan, Chin ^{[1
]}

Zhang, Qian ^{[1
]}

Rao, Chetana ^{[1
]}

Sufi, Bilal ^{[1
]}

Green, Lynae ^{[1
]}

Passmore, David ^{[1
]}

Huber, Mary ^{[1
]}

Chong, Collin ^{[1
]}

Kwok, Eilene ^{[1
]}

Cortez, Orville ^{[1
]}

Passmore, Peter ^{[1
]}

Chen, Liang ^{[1
]}

Gueriavais, Vincent ^{[1
]}

Rangan, Vangiouram ^{[1
]}

Deshpande, Shrikant ^{[1
]}

Cardarelli, Pina ^{[1
]}

King, David ^{[1
]}

Terrett, Jon ^{[1
]}

机构：

[1] Medarex Inc, Sunnyvale, CA USA

来源：

CANCER RESEARCH | 2009年 / 69卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1722

引用

页数：1

共 24 条

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[J]. CHEMICAL COMMUNICATIONS, 2023, 59 (13) : 1841 - 1844
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[J]. BIOMEDICINES, 2023, 11 (11)
[6] Linkers Having a Crucial Role in Antibody-Drug Conjugates
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[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (04)
[7] Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody-Drug Conjugates
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[J]. BIOCONJUGATE CHEMISTRY, 2017, 28 (07) : 1826 - 1833
[8] Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers
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[J]. CANCER RESEARCH, 2019, 79 (13)
[9] Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers
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[J]. MOLECULAR PHARMACEUTICS, 2019, 16 (12) : 4817 - 4825
[10] Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates
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[J]. JOURNAL OF CONTROLLED RELEASE, 2021, 337 : 431 - 447

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