Effects of an isometric strength training on endothelial function in ovariectomized female rats

Introduction. - Ovariectomy in animals reduces endothelium-dependent relaxation. On the other hand, endurance training improves the endothelial function. The purpose of this in vivo study was to investigate, in female Sprague-Dawley rats, the effects of a 14-week progressive strength isometric training on endothelium dysfunction induced by estrogen deficiency. Synthesis. - Rats were randomly divided into 4 groups: 1) sham operated; 2) ovariectomized sedentary group; 3) ovariectomized sedentary group receiving daily injection of 17 beta-estradiol; 4) ovariectomized exercised group. Vascular reactivity of aortic rings has been evaluated by increasing doses of acetylcholine. The acetylcholine-induced relaxation was enhanced in trained rats. Conclusions. - Our data indicate that isometric strength training improves endothelial function in ovariectomized female rats. (c) 2006 Elsevier SAS. Tous droits reserves.