Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: Effects on coagulation, kallikrein-kinin, and complement systems

被引：19
|
作者：
Abe, H
Fujihara, M
Azuma, H
Ikeda, H
Ikebuchi, K
Takeoka, S
Tsuchida, E
Harashima, H
机构：
[1] Hokkaido Red Cross Ctr, Nishi Ku, Sapporo, Hokkaido 0630002, Japan
[2] Waseda Univ, Dept Polymer Chem, Adv Res Inst Sci & Engn, Tokyo 169, Japan
[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Mol Design Pharmaceut, Sapporo, Hokkaido, Japan
[4] Hokkaido Univ, Grad Sch Pharmaceut Sci, COE Program 21 Century, Sapporo, Hokkaido, Japan
来源：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2006年 / 34卷 / 01期
关键词：
oxygen carrier; liposome; hemoglobin vesicles; complement; Kallikrein-Kinin;
D O I：
10.1080/00207450500428204
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hemoglobin vesicles (HbVs), cellular-type artificial oxygen carriers containing human hemoglobin, were assessed for their biocompatibility by mixing with human plasma in vitro . Among three kinds of HbVs (PEG-DPEA-HbV, PEG-DPPG-HbV and DPPG-HbV), PEG-DPEA-HbV did not affect the extrinsic or intrinsic coagulation activities of the plasma, while PEG-DPPG-HbV and DPPG-HbV tended to shorten the intrinsic coagulation time. The kallikrein-kinin cascade of the plasma was slightly activated by PEG-DPPG-HbV and DPPG-HbV, but not by PEG-DPEA-HbV. The complement consumption of the plasma was observed by incubation with DPPG-HbV, but not with PEG-DPEA-HbV or PEG-DPPG-HbV. These results indicate that PEG-DPEA-HbV has a higher biocompatibility with human plasma.
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页码：1 / 10
页数：10
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