Stem cell regulation by JAK/STAT signaling in Drosophila

被引：31
|
作者：
Gregory, Lorna [1 ]
Came, Paul J. [1 ]
Brown, Stephen [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2008年 / 19卷 / 04期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
Review; JAK/STAT; Stem cell; Blood; Germline;
D O I：
10.1016/j.semcdb.2008.06.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. The JAK/STAT pathway has been shown to regulate stem cells during haematopoiesis and gametogenesis in Drosophila. In this review we cover the current literature and contrast each group of stem cells with respect to JAK/STAT signaling. (C) 2008 Published by Elsevier Ltd.
引用
收藏
页码：407 / 413
页数：7
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