Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity

被引：4
|
作者：
Ewald, Andrew J. [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Cell Biol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21218 USA
来源：
EMBO JOURNAL | 2018年 / 37卷 / 07期
关键词：
D O I：
10.15252/embj.201899144
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.
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页数：3
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