Nano-yarns Reinforced Silk Fibroin Composites Scaffold for Bone Tissue Engineering

被引：5

作者：

Li, Jun ^{[1
]}

Liu, Wei ^{[1
]}

Yin, An-Lin ^{[1
]}

Wu, Jing-Lei ^{[1
]}

Al-Deyab, Salem S.

El-Newehy, Mohamed

Mo, Xiu-Mei ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Bioengn, Biomat & Tissue Engn Lab, Shanghai 201620, Peoples R China

来源：

TEXTILE BIOENGINEERING AND INFORMATICS SYMPOSIUM PROCEEDINGS, VOLS 1 AND 2 | 2012年

关键词：

Nano-yarns; Fiber Reinforcement; Liquid-electrospinning; Biornineralization; POROUS 3-D SCAFFOLDS; FABRICATION; HYDROXYAPATITE; NANOFIBER;

D O I：

10.3993/tbis2012023

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this paper, novel nano-yarn reinforced scaffolds were fabricated and further biomineralized by submerging in 10xsimulated body fluid (SBF). The compressive strength of P (LLA-CL)/ Silk fibroin (SF) nano-yarns reinforced scaffold was 1.72 +/- 0.50 MPa and its porosity is 82.8%. Fourier transform infrared spectrum (FTIR) and X-ray diffraction (XRD) data confirmed the mineral phase was made of hydroxyapatite (HA). MC3T3-E1 cell proliferation and differentiation on the scaffolds were evaluated. In vitro biological evaluation showed that HA coated scaffolds provided higher cell proliferation efficiency (t-test, p < 0.05) than uncoated scaffolds.

引用

页码：175 / 183

页数：9

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