Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

被引：5
|
作者：
Kaul, D [1 ]
Kaur, M [1 ]
机构：
[1] Postgrad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Mol Biol Unit, Chandigarh 160012, India
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1999年 / 200卷 / 1-2期
关键词：
mevalonate pathway; CDK inhibitors; receptor-C-k expression; TPA; HL-60 cell line;
D O I：
10.1023/A:1006981614054
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The present study was addressed to understand the interrelationship between Receptor-C-k induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-C-k dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-C-k has an important role in the regulation of cell cycle machinery.
引用
收藏
页码：183 / 186
页数：4
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