MicroRNAs in age-related diseases

被引：148

作者：

Dimmeler, Stefanie ^{[1
,2
]}

Nicotera, Pierluigi ^{[3
]}

机构：

[1] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, D-60054 Frankfurt, Germany

[2] German Ctr Cardiovasc Res DZHK, Frankfurt, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

来源：

EMBO MOLECULAR MEDICINE | 2013年 / 5卷 / 02期

关键词：

cardiac; microRNA; neurodegeneration; senescence; vascular; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL-CELL; DOWN-REGULATION; LIFE-SPAN; EXPRESSION; SENESCENCE; MIR-34A; BRAIN; RNA;

D O I：

10.1002/emmm.201201986

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems. This review is part of the small RNAs review series. See more reviews from this series. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1757-4684/homepage/reviews_smallrnas.htm

引用

页码：180 / 190

页数：11

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