PHARMACOLOGY Inside-out receptor inhibition

被引：3

作者：

Sakmar, Thomas P. ^{[1
]}

Huber, Thomas ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chem Biol & Signal Transduct, New York, NY 10065 USA

来源：

NATURE | 2016年 / 540卷 / 7633期

关键词：

PROTEIN-COUPLED RECEPTOR; ADRENERGIC-RECEPTOR; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; CHEMOKINE; COMPLEX; CXCR4; RECOGNITION; ACTIVATION;

D O I：

10.1038/nature20486

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Structures of two chemokine receptor proteins in complex with small molecules reveal a previously unknown binding pocket that could be a drug target for treating a range of diseases involving this receptor family. See Letters p.458 & p.462

引用

页码：344 / 345

页数：2

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