Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers

被引：57

作者：

Xu, Xiangmin ^{[1
,2
,3
,10
]}

Holmes, Todd C. ^{[4
,10
]}

Luo, Min-Hua ^{[5
,10
]}

Beier, Kevin T. ^{[4
,10
]}

Horwitz, Gregory D. ^{[6
,7
,10
]}

Zhao, Fei ^{[8
,9
]}

Zeng, Wenbo ^{[5
]}

Hui, May ^{[4
]}

Semler, Bert L. ^{[2
,10
]}

Sandri-Goldin, Rozanne M. ^{[2
,10
]}

机构：

[1] Univ Calif Irvine, Sch Med, Dept Anat & Neurobiol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Sch Med, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[4] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[5] Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Ctr Biosafety Megasci, Wuhan Inst Virol,State Key Lab Virol, Wuhan 430071, Peoples R China

[6] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA

[7] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

[8] Capital Med Univ, Sch Basic Med Sci, Beijing 102206, Peoples R China

[9] Chinese Inst Brain Res CIBR, Beijing 102206, Peoples R China

[10] Univ Calif Irvine, Ctr Neural Circuit Mapping, Irvine, CA 92697 USA

来源：

NEURON | 2020年 / 107卷 / 06期

关键词：

VESICULAR STOMATITIS-VIRUS; SITE-SPECIFIC INTEGRATION; TYPE-1 GLYCOPROTEIN K; SEMLIKI-FOREST-VIRUS; ADENOASSOCIATED VIRUS; IN-VIVO; GENE-EXPRESSION; TRANSNEURONAL TRANSPORT; EFFICIENT TRANSDUCTION; AXONAL-TRANSPORT;

D O I：

10.1016/j.neuron.2020.07.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer on currently applied anterograde and retrograde viral tracers with practical guidance on experimental uses. We also discuss and highlight key technical and conceptual considerations for developing new safer and more effective anterograde trans-synaptic viral vectors for neural circuit analysis in multiple species.

引用

页码：1029 / 1047

页数：19

共 47 条

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