Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients

被引：2
|
作者：
Thyagarajan, Bharat [1 ]
Arora, Mukta [2 ]
Guan, Weihua [3 ]
Barcelo, Helene [1 ]
Jackson, Scott [4 ]
Kumar, Shaji [5 ]
Gertz, Morie [5 ]
机构：
[1] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Div Hematol Oncol & Transplantat, Dept Med, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Mason Canc Ctr, Biostat & Informat Core, Minneapolis, MN 55455 USA
[5] Mayo Clin, Div Hematol, Dept Med, Rochester, MN USA
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 11期
关键词：
Multiple myeloma; Melphalan; Autologous transplantation; Nucleotide excision repair; Base excision repair; Single nucleotide polymorphisms; Disease progression; STEM-CELL SUPPORT; IMPROVED SURVIVAL; EXCISION-REPAIR; MELPHALAN; POLYMORPHISMS; IMPACT; TRANSPLANTATION; CHEMOTHERAPY; THERAPY; ADDUCTS;
D O I：
10.1016/j.leukres.2013.07.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n = 311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p = 0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1527 / 1531
页数：5
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