Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid-Bronsted acid via an SN1-type pathway

被引：21

作者：

Zhang, Tao ^{[1
,2
]}

Qiao, Zhen ^{[1
,2
]}

Wang, Yan ^{[1
,2
]}

Zhong, Nengjun ^{[1
,2
]}

Liu, Li ^{[1
]}

Wang, Dong ^{[1
]}

Chen, Yong-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, BNLMS, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 16期

基金：

中国国家自然科学基金;

关键词：

GAMMA-ALKYLATION; ALDEHYDES; ALCOHOLS; ORGANOCATALYSIS; ION; DIHYDROXYLATION; RESOLUTION; OXINDOLES; INDOLES; OLEFINS;

D O I：

10.1039/c3cc39012h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective direct alpha-alkylation of 2-oxindoles with Michler's hydrol via an S(N)1-type pathway in the non-covalent activation mode using the bis-cinchona alkaloid and Bronsted acid as a co-catalyst was developed and good to high yields and enantioselectivities were obtained.

引用

页码：1636 / 1638

页数：3