Synthesis and biological activity of novel tricyclic beta-lactams

被引:13
|
作者
Biondi, S [1 ]
Gaviraghi, G [1 ]
Rossi, T [1 ]
机构
[1] GLAXO RES LABS,DEPT MED CHEM,I-37100 VERONA,ITALY
关键词
D O I
10.1016/0960-894X(96)00061-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis and the preliminary data on microbiological activity of some tricyclic beta-lactam derivatives (4), analogues of synthetic ''trinems'', is described. Compound 14, key intermediate in the synthesis of 18, was stereoselectively obtained from its unsubstituted analogue, 12b, in 4 steps through enolphosphate 13.
引用
收藏
页码:525 / 528
页数:4
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