Synthesis and biological activity of novel tricyclic beta-lactams

被引：13

作者：

Biondi, S ^{[1
]}

Gaviraghi, G ^{[1
]}

Rossi, T ^{[1
]}

机构：

[1] GLAXO RES LABS,DEPT MED CHEM,I-37100 VERONA,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/0960-894X(96)00061-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the preliminary data on microbiological activity of some tricyclic beta-lactam derivatives (4), analogues of synthetic ''trinems'', is described. Compound 14, key intermediate in the synthesis of 18, was stereoselectively obtained from its unsubstituted analogue, 12b, in 4 steps through enolphosphate 13.

引用

页码：525 / 528

页数：4

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