Expression of heat shock protein 70 and p53 in human lung cancer

被引：1
|
作者：
Costa, MJM
Rosas, SLB
Chindano, A
Lima, PDS
Madi, K
Carvalho, MDD
机构：
[1] UNIV FED RIO DE JANEIRO, INST BIOFIS CARLOS CHAGAS FILHO, LAB CONTROLE EXPRESSAO GEN, BR-21949900 RIO DE JANEIRO, BRAZIL
[2] UNIV FED RIO DE JANEIRO, HOSP UNIV CLEMENTINO FRAGA FILHO, DEPT CLIN MED, SERV PNEUMOL, BR-21949900 RIO DE JANEIRO, BRAZIL
[3] UNIV FED RIO DE JANEIRO, DEPT PATHOL, SERV ANAT PATOL, BR-21949900 RIO DE JANEIRO, BRAZIL
来源：
ONCOLOGY REPORTS | 1997年 / 4卷 / 05期
关键词：
stress protein; p53; HSP70; lung cancer;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bronchial biopsies of 21 patients with lung cancer were analyzed by Western blot for stress protein HSP70 and p53 proteins. Squamous carcinoma was the most common type found. The p53 protein was detectable in 14 cases. The HSP70 was detectable in 17 and overexpressed in 9 patients. Eleven patients showed positivity for both protein expressions, however no statistical significance was found (Kappa's test, p>0.05). Specific associations were not observed for HSP70 overexpression and p53 detection that could be related to clinical finds or tabagism. Our results indicate that the stress protein HSP70 is detectable and may be involved in the tumor development.
引用
收藏
页码：1113 / 1116
页数：4
相关论文
共 50 条
  • [1] Regulation of cutaneous heat shock protein 70 (HSP70) expression by p53
    Trotter, MJ
    Quenneville, LA
    Li, HY
    Zhou, X
    Tron, VA
    LABORATORY INVESTIGATION, 1999, 79 (01) : 64A - 64A
  • [2] P53 and heat shock protein 70 expressions in colorectal adenocarcinoma
    Shotar, AM
    SAUDI MEDICAL JOURNAL, 2005, 26 (10) : 1602 - 1606
  • [3] ON THE EXPRESSION OF THE P53 PROTEIN IN HUMAN CANCER
    LANE, DP
    MOLECULAR BIOLOGY REPORTS, 1994, 19 (01) : 23 - 29
  • [4] P53 MUTATIONS, RAS MUTATIONS, AND P53-HEAT SHOCK 70 PROTEIN COMPLEXES IN HUMAN LUNG-CARCINOMA CELL-LINES
    LEHMAN, TA
    BENNETT, WP
    METCALF, RA
    WELSH, JA
    ECKER, J
    MODALI, RV
    ULLRICH, S
    ROMANO, JW
    APPELLA, E
    TESTA, JR
    GERWIN, BI
    HARRIS, CC
    CANCER RESEARCH, 1991, 51 (15) : 4090 - 4096
  • [5] p53 protein, TP53 mutation and heat shock protein 70 kDa (Hsp70) detection in patients with esophageal cancer
    Kawamura, MT
    Costa, MJM
    Mendonca, AM
    Ribeiro, IP
    Romano, S
    Carvalho, RLT
    Carvalho, MGC
    17TH INTERNATIONAL CANCER CONGRESS, VOL 1 AND 2, 1998, : 885 - 889
  • [6] The expression of heat shock protein 70 in human gastric cancer
    Shomori, K
    Ishida, M
    Ikeda, M
    Ohfuji, S
    Tatebe, S
    Osaki, M
    Ito, H
    RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, : 389 - 393
  • [7] Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer
    Maehara, Y
    Oki, E
    Abe, T
    Tokunaga, E
    Shibahara, K
    Kakeji, Y
    Sugimachi, K
    ONCOLOGY, 2000, 58 (02) : 144 - 151
  • [8] Is p53 and heat shock protein 70 expression a useful parameter for preoperative hyperthermoradiation therapy in advanced rectal carcinoma
    Takeuchi, Kunio
    Nakajima, Masanobu
    Miyazaki, Tatsuya
    Ide, Munenori
    Asao, Takayuki
    Fujita, Kin'ichi
    Kuwano, Hiroyuki
    HEPATO-GASTROENTEROLOGY, 2007, 54 (74) : 367 - 372
  • [9] NATURAL STATE OF MUTANT P53 PROTEIN AND HEAT-SHOCK PROTEIN-70 IN BREAST-CANCER TISSUES
    IWAYA, K
    TSUDA, H
    FUJITA, S
    SUZUKI, M
    HIROHASHI, S
    LABORATORY INVESTIGATION, 1995, 72 (06) : 707 - 714
  • [10] Study of p53 and heat shock protein (HSP) manifestations in bladder cancer
    Jang, Seok Heun
    Kim, Jae Il
    Son, Jeong Hwan
    INTERNATIONAL JOURNAL OF UROLOGY, 2010, 17 : A302 - A303
12345