Effect of bunching of cilia and their interplay on muco-ciliary transport

被引：9

作者：

Roy, Yagnaseni ^{[1
]}

Sivathanu, Vivek ^{[2
]}

Das, Sarit K. ^{[3
]}

机构：

[1] SRM Univ, Dept Mech Engn, Madras 603203, Tamil Nadu, India

[2] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[3] Indian Inst Technol, Dept Mech Engn, Madras 603203, Tamil Nadu, India

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2013年 / 43卷 / 11期

关键词：

Mucous; Cilia; Muco-ciliary clearance; Ciliary patches; Inter-patch interaction; Ciliary beating; Metachronic wave; TRACHEAL EPITHELIUM; BEAT FREQUENCY; NASAL CILIA; DYSKINESIA; CLEARANCE; CILIOPATHIES; DIAGNOSIS; GENETICS; GEOMETRY; BIOLOGY;

D O I：

10.1016/j.compbiomed.2013.08.014

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cilia are hair-like organelles projecting from a eukaryotic cell, used either for locomotion or as sensors. Cilia commonly occur in patches. To take this into consideration, we represent cilia in multiple patches, instead of the conventional 'dense mat' representation. We focus on the combined action and interplay of these patches. The effects of varying the frequency, spacing and phase lag of the beating of one cilia bunch with respect to the beating of adjacent patches are studied. We model the Airway Surface Liquid (ASL) as a three-layer structure. The possibility of an optimum frequency of beating is noted and the change of mucous flow under different spacing and phase differences are observed. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1758 / 1772

页数：15

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