Objective. To describe smoking cessation therapies available in Mexico. Material and Methods. Literature review of meta-analysis, controlled clinical trials, and behavioral therapy studies. Results. Smoking cessation pharmacotherapy interventions showed a good chance of success on average, expressed as the ratio of the active drug vs. placebo cessation therapy outcomes (ratios of 39, 78, 79, 117, and 119%, for nicotine chewing gum, bupropion, nicotine patch, inhaler, and nicotine nasal spray, respectively). Behavioral therapy showed satisfactory results, (OR = 3.8) however, more research is needed to establish its effectiveness. Conclusions. Emphasis is made on the need to combine behavioral therapy with pharmacotherapy, to increase the likelihood of successful smoking cessation. The English version of this paper is available at: http://www.insp.mx/salud/ index.html.