Recommendations for the use of Rituximab in neuromyelitis optica spectrum disorders

被引:53
|
作者
Ciron, J. [1 ,2 ]
Audoin, B. [3 ,4 ]
Bourre, B. [5 ]
Brassat, D. [1 ,6 ]
Durand-Dubief, F. [7 ]
Laplaud, D. [8 ]
Maillart, E. [9 ]
Papeix, C. [9 ]
Vukusic, S. [7 ,10 ,11 ]
Zephir, H. [12 ]
Marignier, R. [7 ,13 ]
Collongues, N. [14 ,15 ,16 ]
机构
[1] Univ Hosp Toulouse, Hop Pierre Paul Riquet, Dept Neurol, Pole Neurosci, Pl Dr Baylac, F-31059 Toulouse 9, France
[2] Univ Hosp Poitiers, Dept Neurol, Pole Neurosci Locomoteur, 2 Rue Miletrie, F-86021 Poitiers, France
[3] Hop La Timone, AP HM, Pole Neurosci Clin, Dept Beurol, F-13005 Marseille, France
[4] Aix Marseille Univ, CRMBM, CNRS, UMR 7339, F-13005 Marseille, France
[5] Univ Hosp Rouen, Dept Neurol, F-76000 Rouen, France
[6] Univ Toulouse III, UMR 1043, F-31400 Toulouse, France
[7] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Dept Neurol Sclerose Plaques Pathol Myeline & Neu, F-69677 Lyon, France
[8] Univ Hosp Nantes, Dept Neurol, F-44093 Nantes, France
[9] Hop La Pitie Salpetriere, AP HP, Dept Neurol, F-75013 Paris, France
[10] CNRS, INSERM, Observ Francais Sclerose Plaques, Ctr Neurosci Lyon,U1028,UMR 5292, F-69003 Lyon, France
[11] Univ Lyon 1, F-69003 Lyon, France
[12] Univ Hosp Lille, Dept Neurol, F-59037 Lille, France
[13] CNRS, Ctr Rech Neurosci Lyon, FLUID Team, Fac Med Laennec,INSERM,U1028,UMR 5292, F-69008 Lyon, France
[14] Univ Hosp Strasbourg, Dept Neurol, F-67200 Strasbourg, France
[15] Univ Hosp Strasbourg, INSERM, Clin Invest Ctr, U1434, F-67200 Strasbourg, France
[16] Univ Hosp Strasbourg, INSERM, Biopathol Myelin, Neuroprotect & Therapeut Strategies,U1119, F-67200 Strasbourg, France
关键词
Neuromyelitis optica; Rituximab; Guidelines; Recommendations; Treatment; ACTIVE RHEUMATOID-ARTHRITIS; LOW-DOSE RITUXIMAB; MEMORY B-CELLS; MULTIPLE-SCLEROSIS; ANTI-AQP4; ANTIBODY; DOUBLE-BLIND; FOLLOW-UP; PREGNANCY; EFFICACY; MULTICENTER;
D O I
10.1016/j.neurol.2017.11.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is growing evidence of a preventive effect of Rituximab (RTX) in neuromyelitis optica spectrum disorders (NMO-SD). This monoclonal antibody against CD20 is becoming the most widely used preventive therapy in NMO-SD, as a first-line therapy or as a rescue therapy. Nevertheless, considerable heterogeneity still exists concerning the pre-treatment work-up, the vaccinations required before and under treatment, the number and dosage of infusions, prevention of the risk of infusion-related reactions, prevention of infections under treatment, and frequency of therapeutic cycles. Thanks to a collaborative work among NMO-SD experts belonging to the NOMADMUS project, we provide here recommendations for all these topics concerning RTX use in NMO-SD. (C) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:255 / 264
页数:10
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