Neuropathologic correlates of apathy in Alzheimer's disease

被引：110

作者：

Marshall, GA

Fairbanks, LA

Tekin, S

Vinters, HV

Cummings, JL

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Reed Neurol Res Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Psychiat & Biobehav Neurosci, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Pathol & Lab Med Neuropathol, Los Angeles, CA 90095 USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2006年 / 21卷 / 03期

关键词：

apathy; Alzheimer's disease; behavioral disturbances; neuritic plaques; neurofibrillary tangles;

D O I：

10.1159/000090674

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Apathy is the most commonly observed behavioral disturbance in Alzheimer's disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：144 / 147

页数：4

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