The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland

被引：35

作者：

Kluzniak, Wojciech ^{[1
]}

Wokolorczyk, Dominika ^{[1
]}

Kashyap, Aniruddh ^{[1
]}

Jakubowska, Anna ^{[1
]}

Gronwald, Jacek ^{[1
]}

Huzarski, Tomasz ^{[1
]}

Byrski, Tomasz ^{[1
]}

Debniak, Tadeusz ^{[1
]}

Golab, Adam ^{[2
]}

Gliniewicz, Bartlomiej ^{[2
,3
]}

Sikorski, Andrzej ^{[2
]}

Switala, Jerzy ^{[3
]}

Borkowski, Tomasz ^{[4
]}

Borkowski, Andrzej ^{[4
]}

Antczak, Andrzej ^{[5
]}

Wojnar, Lukasz ^{[5
]}

Przybyla, Jacek ^{[6
]}

Sosnowski, Marek ^{[6
]}

Malkiewicz, Bartosz ^{[7
]}

Zdrojowy, Romuald ^{[7
]}

Sikorska-Radek, Paulina ^{[8
]}

Matych, Jozef ^{[8
]}

Wilkosz, Jacek ^{[9
]}

Rozanski, Waldemar ^{[9
]}

Kis, Jacek ^{[10
]}

Bar, Krzysztof ^{[10
]}

Bryniarski, Piotr ^{[11
]}

Paradysz, Andrzej ^{[11
]}

Jersak, Konrad ^{[12
]}

Niemirowicz, Jerzy ^{[12
]}

Slupski, Piotr ^{[13
]}

Jarzemski, Piotr ^{[13
]}

Skrzypczyk, Michal ^{[14
]}

Dobruch, Jakub ^{[14
]}

Domagala, Pawel ^{[15
]}

Akbari, Mohammad R.

Lubinski, Jan ^{[1
]}

Narod, Steven A. ^{[16
]}

Cybulski, Cezary ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, PL-70115 Szczecin, Poland

[2] Pomeranian Med Univ, Urol Clin, PL-70115 Szczecin, Poland

[3] Maria Sklodowska Curie Hosp, Div Urol, Szczecin, Poland

[4] Med Univ, Dept Urol, Warsaw, Poland

[5] Med Univ, Chair Urol, Poznan, Poland

[6] Med Univ Lodz, Dept Urol, Lodz, Poland

[7] Univ Med, Dept Urol & Urol Oncol, Wroclaw, Poland

[8] Reg Hosp, Div Urol, Lodz, Poland

[9] Med Univ Lodz, Dept Urol 2, Lodz, Poland

[10] Univ Hosp Lublin, Dept Urol, Lublin, Poland

[11] Med Univ Silesia, Dept Urol, Zabrze, Poland

[12] Minist Internal Affairs & Adm Hosp, Dept Urol, Lodz, Poland

[13] J Biziel Hosp, Dept Urol, Bydgoszcz, Poland

[14] Ctr Postgrad Urol Educ, Dept Urol, Warsaw, Poland

[15] Pomeranian Med Univ, Dept Pathol, PL-70115 Szczecin, Poland

[16] Ctr Res Womens Hlth, Toronto, ON, Canada

来源：

PROSTATE | 2013年 / 73卷 / 05期

关键词：

G84E mutation; HOXB13; prostate cancer; GERMLINE MUTATIONS; SUSCEPTIBILITY GENE; ASHKENAZI-JEWS; BRCA2; CHEK2; MEN; HPC2/ELAC2; VARIANTS; LINKAGE; IMPACT;

D O I：

10.1002/pros.22594

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. METHODS We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele. RESULTS The G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR]=5.0; 95% CI: 1.516.7; P=0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR=8.4, 95% CI: 1.937.7; P=0.005). CONCLUSIONS The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations. Prostate 73: 542548, 2013. (c) 2013 Wiley Periodicals, Inc.

引用

页码：542 / 548

页数：7

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