CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation

被引：30
|
作者：
Joffre, O [1 ]
van Meerwijk, JPM [1 ]
机构：
[1] Univ Toulouse 3, INSERM, U563, Tolerance & Autoimmun Sect,Purpan Hosp, F-31024 Toulouse 3, France
来源：
SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 02期
关键词：
transplantation; immunoregulation; regulatory T lymphocytes; suppressor T lymphocytes; bone marrow;
D O I：
10.1016/j.smim.2006.01.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：128 / 135
页数：8
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