SNAP-25 gene variations and attention- deficit hyperactivity disorder in Iranian population

被引：2
|
作者：
Alhosseini, Mahjoubeh Zarrabi [1 ]
Jamshidi, Javad [2 ]
Bidoki, Alireza Zare [3 ]
Ganji, Saeid [4 ]
Amirabadi, Mohammad Reza Eslami [5 ]
Emamalizadeh, Babak [6 ]
Taghavi, Shaghayegh [6 ]
Shokraeian, Parasto [7 ]
Mohajerani, Fatemeh [8 ]
Darvish, Hossein [6 ]
机构：
[1] Islamic Azad Univ, Shahrekord Branch, Dept Biol, Fac Basic Sci, Shahrekord, Iran
[2] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran
[3] Univ Tehran Med Sci, Mol Immunol Res Ctr, Tehran, Iran
[4] Mashhad Univ Med Sci, Mehr Hosp, Mashhad, Iran
[5] Shahid Behashti Univ Med Sci, Imam Hossein Med Hosp, Dept Psychiat, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
[7] Islamic Azad Univ, Tehran Med Sci Branch, Tehran, Iran
[8] Islamic Azad Univ, Tehran Med Branch, Adv Sci & Technol Fac, Tehran, Iran
来源：
NEUROLOGICAL RESEARCH | 2016年 / 38卷 / 11期
关键词：
ADHD; SNAP-25; Variation; Polymorphism; Iranian; DEFICIT/HYPERACTIVITY DISORDER; COMMON VARIANTS; CANDIDATE GENE; ADHD; ASSOCIATION; SUSCEPTIBILITY; POLYMORPHISMS; METHYLPHENIDATE; PLASTICITY; SNAP25;
D O I：
10.1080/01616412.2016.1232548
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa (SNAP-25) gene variants with ADHD. Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6-16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6-16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP-25 gene were genotyped. Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD. Discussion: To our knowledge, it is the first report of SNAP-25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD.
引用
收藏
页码：959 / 964
页数：6
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