The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy

被引：40
|
作者：
Chang, Ting-Ting [1 ]
Chen, Jaw-Wen [1 ,2 ,3 ,4 ]
机构：
[1] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 11221, Taiwan
[2] Taipei Vet Gen Hosp, Dept Med Res, Taipei 11217, Taiwan
[3] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 11221, Taiwan
[4] Taipei Vet Gen Hosp, Dept Med, Taipei 11217, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 09期
关键词：
chemokine; chemokine receptor; diabetic nephropathy; diabetes mellitus; inflammation; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACTIVATED KINASE 1; NF-KAPPA-B; OXIDATIVE STRESS; RENAL INJURY; INFLAMMATORY RESPONSE; UP-REGULATION; EXTRACELLULAR-MATRIX; FRACTALKINE CX3CL1; MCP-1; EXPRESSION;
D O I：
10.3390/ijms21093172
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN.
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页数：16
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