Long Range Linkage Disequilibrium across the Human Genome

被引：34
|
作者：
Koch, Evan [1 ]
Ristroph, Mickey [1 ]
Kirkpatrick, Mark [1 ]
机构：
[1] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA
来源：
PLOS ONE | 2013年 / 8卷 / 12期
基金：
美国国家科学基金会;
关键词：
RECENT POSITIVE SELECTION; HAPLOTYPE MAP; ASSOCIATION; CHROMOSOME; REGION; GENE;
D O I：
10.1371/journal.pone.0080754
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the disequilibrium between all pairs of SNPs on each chromosome (a total of > 26x10(11) values) and evaluated significance of overall disequilibrium using randomization. The results show an excess of associations between pairs of distant sites (separated by > 0.25 cM) on all of the 22 autosomes. We discuss possible explanations for this observation.
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页数：10
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