The influence of individual susceptibility in pyrethroid exposure

被引：26
|
作者：
Leng, G
Lewalter, J
Röhrig, B
Idel, H
机构：
[1] Univ Dusseldorf, Inst Hyg, D-40225 Dusseldorf, Germany
[2] Bayer AG, Med Serv, D-51368 Leverkusen, Germany
来源：
TOXICOLOGY LETTERS | 1999年 / 107卷 / 1-3期
关键词：
pyrethroids; individual susceptibility; symptoms; half-life time of cyfluthrin in plasma; half-life time of metabolites in urine; carboxylesterase activity in lymphocytes;
D O I：
10.1016/S0378-4274(99)00039-9
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The aim of this study was to find a suitable biomarker for pyrethroid adverse effects. It was shown that there is a correlation between the half-life time (t(1/2)) of pyrethroids in plasma and the clinical findings. We hypothized that this finding indicates an interindividual different amount of total esterase activity or even a polymorphism. By in vitro experiments it was demonstrated that pyrethroids are cleaved by carboxylesterases. After it turned out that carboxylesterase activity in human plasma is too low for detection, a method for specific determination of carboxylesterase activity in human isolated lymphocytes was developed. As a substrate for carboxylesterase activity, cyfluthrin was added to the lymphocyte suspension. As a proof for cyfluthrin degradation by carboxylesterases the produced hydrocyanic acid was determined by GC/MS. First hints for interindividual differences in carboxylesterase activity in lymphocytes were found. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：123 / 130
页数：8
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