Toxoplasma-SPECIFIC IgG SUBCLASS ANTIBODY RESPONSE IN CEREBROSPINAL FLUID SAMPLES FROM PATIENTS WITH CEREBRAL TOXOPLASMOSIS

被引：3
|
作者：
Nascimento, Fernanda S. [1 ]
Suzuki, Lisandra A. [1 ]
Branco, Nilson [2 ]
Franco, Regina M. B. [2 ]
Andrade, Paula D. [3 ]
Costa, Sandra C. B. [3 ]
Pedro, Marcelo N. [3 ]
Rossi, Claudio L. [1 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Patol Clin, BR-13083887 Campinas, SP, Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Biol Anim, BR-13083887 Campinas, SP, Brazil
[3] Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Med Interna, BR-13083887 Campinas, SP, Brazil
来源：
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2015年 / 57卷 / 05期
关键词：
Cerebral toxoplasmosis; Cerebrospinal fluid; IgG subclasses; HIV-INFECTED PATIENTS; CONGENITAL TOXOPLASMOSIS; GONDII INFECTION; ANTIGENS; ENCEPHALITIS; DIAGNOSIS;
D O I：
10.1590/S0036-46652015000500013
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Cerebral toxoplasmosis can be highly debilitating and occasionally fatal in persons with immune system deficiencies. In this study, we evaluated the Toxoplasma gondii-specific IgG subclass antibody response in 19 cerebrospinal fluid (CSF) samples from patients with cerebral toxoplasmosis who had a positive IgG anti-T. gondii ELISA standardized with a cyst antigen preparation. There were no significant differences between the rates of positivity and the antibody concentrations (arithmetic means of the ELISA absorbances, MEA) for IgG(1) and IgG(2), but the rates of positivity and MEA values for these two IgG subclasses were significantly higher than those for IgG(3) and IgG(4). The marked IgG(2) response in CSF from patients with cerebral toxoplasmosis merits further investigation.
引用
收藏
页码：439 / 442
页数：4
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