A Thermostable mRNA Vaccine against COVID-19

被引：496

作者：

Zhang, Na-Na ^{[1
,2
]}

Li, Xiao-Feng ^{[1
]}

Deng, Yong-Qiang ^{[1
]}

Zhao, Hui ^{[1
]}

Huang, Yi-Jiao ^{[1
]}

Yang, Guan ^{[3
]}

Huang, Wei-Jin ^{[4
]}

Gao, Peng ^{[5
]}

Zhou, Chao ^{[1
]}

Zhang, Rong-Rong ^{[1
]}

Guo, Yan ^{[1
]}

Sun, Shi-Hui ^{[1
]}

Fan, Hang ^{[1
]}

Zu, Shu-Long ^{[1
]}

Chen, Qi ^{[1
]}

He, Qi ^{[3
]}

Cao, Tian-Shu ^{[1
]}

Huang, Xing-Yao ^{[1
]}

Qiu, Hong-Ying ^{[1
]}

Nie, Jian-Hui ^{[4
]}

Jiang, Yuhang ^{[5
]}

Yan, Hua-Yuan ^{[5
]}

Ye, Qing ^{[1
]}

Zhong, Xia ^{[5
]}

Xue, Xia-Lin ^{[5
]}

Zha, Zhen-Yu ^{[5
]}

Zhou, Dongsheng ^{[1
]}

Yang, Xiao ^{[3
]}

Wang, You-Chun ^{[4
]}

Ying, Bo ^{[5
]}

Qin, Cheng-Feng ^{[1
]}

机构：

[1] Acad Mil Med Sci, Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

[2] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

[3] Beijing Inst Life, Natl Ctr Prot Sci Beijing, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 102206, Peoples R China

[4] Natl Inst Food & Drug Control NIFDC, Inst Biol Prod Control, Div HIV AIDS & Sex Transmitted Virus Vaccines, Beijing 102629, Peoples R China

[5] Suzhou Abogen Biosci Co Ltd, Suzhou 215123, Peoples R China

来源：

CELL | 2020年 / 182卷 / 05期

关键词：

INFECTION;

D O I：

10.1016/j.cell.2020.07.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19) because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA (mRNA)-based vaccine has emerged as a rapid and versatile platform to quickly respond to this challenge. Here, we developed a lipid nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (called ARCoV). Intramuscular immunization of ARCoV mRNA-LNP elicited robust neutralizing antibodies against SARS-CoV-2 as well as a Th1-biased cellular response in mice and non-human primates. Two doses of ARCoV immunization in mice conferred complete protection against the challenge of a SARS-CoV-2 mouse-adapted strain. Additionally, ARCoV is manufactured as a liquid formulation and can be stored at room temperature for at least 1 week. ARCoV is currently being evaluated in phase 1 clinical trials.

引用

页码：1271 / +

页数：29

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