Macrocycle opening in crown compounds -: 4.: Steric effects in the ring-opening reaction of the macrocycle of 4′-nitrobenzo-15-crown-5 ether under the action of amines to form podands

The regioselective nucleophilic opening of the macrocycle of 4'-nitrobenzo-15-crown-5 ether under the action of amines with various structures to form nitrogen-containing podands was studied. A distinguishing characteristic feature of this reaction with aminoalcohols is the ability of the latter to form hydrogen bonds, resulting in an increase in the degree of conversion into podands.