MicroRNA mediates DNA methylation of target genes

被引：21

作者：

Hu, Wangxiong ^{[1
,2
,3
]}

Wang, Tingzhang ^{[4
]}

Xu, Jianhong ^{[4
]}

Li, Hongzhi ^{[3
]}

机构：

[1] Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Hangzhou 310058, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China

[4] Zhejiang Univ, Zhejiang Key Lab Crop Germplasm, Inst Crop Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 444卷 / 04期

关键词：

DNA methylation; Gene ontology; MicroRNA; RNA-directed DNA methylation; GENOME-WIDE ANALYSIS; DOWN-REGULATION; EVOLUTION; RNA; BIOGENESIS; EXPRESSION;

D O I：

10.1016/j.bbrc.2014.01.171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small RNAs represented by microRNA (miRNA) plays important roles in plant development and responds to biotic and abiotic stresses. Previous studies have placed special emphasis on gene-repression mediated by miRNA. In this work, the DNA methylation pattern of microRNA genes (MIRs) was interrogated. Full-length cDNA and EST were used to confirm the entity of pri-miRNA. In parallel, miRNA in 24 nucleotides (nt) was pooled to detect chromatin modification effect by using bisulfite sequencing data. 97 MIRs were supported by full-length cDNA and 30 more were hit by EST. Notably, methylation levels of conserved MIRs were significantly lower than the non-conserved at all contexts (CG, CHG, and CHH). Additionally, a substantial part of 24-nt miRNA was able to induce target site methylation, providing a broader perspective for researchers. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：676 / 681

页数：6

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