Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells

被引：72
|
作者：
Steiner, Alexandre A.
Chakravarly, Sumana
Rudaya, Alla Y.
Herkenham, Miles
Romanovsky, Andrej A.
机构：
[1] St Josephs Hosp, Systemat Inflammat Lab, Phoenix, AZ 85013 USA
[2] Med Ctr, Phoenix, AZ USA
[3] NIMH, Funct Neuroanat Sect, NIH, Bethesda, MD 20892 USA
来源：
BLOOD | 2006年 / 107卷 / 10期
关键词：
D O I：
10.1182/blood-2005-11-4743
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lipopolysaccharide (LPS), a well-known bacterial pyrogen, is recognized by several receptors, including the Toll-like receptor 4 (TLR4), on various cells. Which of these receptors and cells are linked to fever production is unknown. By constructing 4 mouse chimeras and studying their thermoregulatory responses, we found that all 3 phases of the typical LIPS fever depend on TLR4 signaling. The first phase is triggered via the TLR4 on hematopoietic cells. The second and third phases involve TLR4 signaling in both hematopoietic and nonhematopoietic cells.
引用
收藏
页码：4000 / 4002
页数：3
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