Predilution On-Line Hemodiafiltration Improves Albumin Redox in Maintenance Hemodialysis Patients

被引:7
|
作者
Shigematsu, Takeshi [1 ]
Kuragano, Takahiro [2 ]
Kamimura, Takenobu [1 ]
Kawada, Sayuri [1 ]
Imamura, Rie [1 ]
Nishian, Yoshihiko [1 ]
Miyamoto, Miki [2 ]
Miyamoto, Takashi [1 ]
Nakanishi, Takeshi [2 ,3 ]
机构
[1] Heiseikai Miyamoto Clin, Nishinomiya, Hyogo, Japan
[2] Hyogo Coll Med, Dept Internal Med, Div Kidney & Dialysis, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan
[3] Gojinkai Sumiyoshigawa Hosp, Dept Nephrol, Kobe, Hyogo, Japan
关键词
Predilution on-line hemodiafiltration; Oxidative stress; Inflammation; Nutrition; Human mercapto albumin ratio; ALL-CAUSE MORTALITY; STRESS; SERUM;
D O I
10.1159/000496631
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aim: In this study, we compared the dialysis efficiency, oxidative stress, and nutritional conditions between predilution on-line hemodiafiltration (pre-OL-HDF) and conventional hemodialysis (HD) using a super-flux dialyzer (CHD). Method: This was a crossover study of 38 maintenance HD patients. All patients were treated with CHD for the first 4 months (1st CHD period), then were switched to pre-OL-HDF for 4 months (pre-OL-HDF period), and were returned to CHD for the next 4 months (2nd CHD period). Results: We found no significant difference in the removal ratio of small uremic substances or the indices of inflammation or nutritional states between the pre-OL-HDF and CHD periods. However, we found higher removal of beta 2 micro-globulin in the pre-OL-HDF period, and the human mercapto-albumin (Alb)/human serum Alb ratio was significantly higher in the pre-OL-HDF period. Conclusion: Treatment with pre-OLHDF enabled enhanced removal of middle molecule uremic toxins and better Alb redox than did CHD. (c) 2019 S. Karger AG, Basel
引用
收藏
页码:19 / 24
页数:6
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