Gallium(III) Triflate Catalyzed Diastereoselective Mukaiyama Aldol Reaction by Using Low Catalyst Loadings

被引：3

作者：

Plancq, Baptiste ^{[1
]}

Justafort, Lyse Carole ^{[1
]}

Lafantaisie, Mathieu ^{[1
]}

Ollevier, Thierry ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Quebec City, PQ G1V 0A6, Canada

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 29期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

Gallium; Aldol reactions; Lewis acids; C-C bond formation; SILYL ENOL ETHERS; C-2-SYMMETRIC COPPER(II) COMPLEXES; LEWIS-ACID; CARBONYL-COMPOUNDS; ADDITIONS; ENOLSILANES; ALLYLATION; ALDEHYDES; SOLVENT; ACETALS;

D O I：

10.1002/ejoc.201301100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild method for the diastereoselective Mukaiyama aldol reaction is reported. By using a low loading of the gallium(III) triflate catalyst (down to 0.01 mol-%), the transformation proceeds efficiently to afford the corresponding -hydroxy ketones in yields up to 92%. To the best of our knowledge, this is the first report of a metal triflate acting as a safe, bench-stable, and slow-releasing source of triflic acid for the Mukaiyama aldol reaction.

引用

页码：6525 / 6529

页数：5

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